Fatty Acid Biosynthesis To The Tune Of Men Of Harlech Chords & Lyrics - Misc Your Songs - Harold Baum

Capo on 3 - These chords work ok for this Biochemistry-ised version of the Welsh battle song.

[VERSE 1]
[G]If you [C]gobble [G]taglia[Em]telli,
[C]Chicken [Am]soup with [D]vermcilli,
[G]You’ll ac[C]quire a [G]sagging [Em]belly –
[G]What’s the [D]use of [G]that?

[VERSE 2]
[G]If your [C]intake’s [G]calor[Em]ific,
[C]Guzzling [Am]beer till [D]soporific,
[G]Possi[C]bly you’ll [G]feel ter[Em]rific,
[G]But you’ll [D]end up [G]fat.

[REFRAIN 1]
[D]Fat against starvation;
[G]Fat for insulation;
[G]If you sit hard you’ll bounce on lard
[G]Which substitutes in females for inflation.
[C]Fat pro[G]vides when [Am]you are [G]needing
[Am]Glucogenic when [D]you’re seeding
[G]Product [C]of ex[G]cessive [Em]feeding
[G]Hail Ad[D]ipo[G]cyte!

[VERSE 3]
That [G]cell does [C]not be[G]lieve in [Em]spurning
[C]Excess [Am]food that [D]it's not burning.
[G]Therefore [C]carboy[G]hdrate [Em]turning
[G]To an [D]ace[G]tyl

[VERSE 4]
[G]Trapped [C]inside the [G]matrix [Em]spaces
[C]CoA [Am]esters [D]in such places
[G]Need to [C]show some [G]fancy [Em]paces
[G]And a [D]dash of [G]style

[REFRAIN 2]
[D]Hence, citrate formation,
[G]Anion translocation
[G](The other way, goes malate,say)
[G]And cleavage then reverses condensation
[C]Ace[G]tyl Co[Am]A for[G]mation
[Am]Outside ready [D]for ligation
[G]Now forms [C]by car[G]boxy[Em]lation
[G]Malo[D]nyl Co[G]A.

[VERSE 5]
[G]Fatty [C]acid [G]synthe[Em]tase is
[C]So comp[Am]lex that [D]it amazes
[G]By the [C]subtle [G]inter[Em]phases
[G]Between [D]every [G]piece.

[VERSE 6]
[G]Twice we [C]find a [G]thiol [Em]centre
[C]Through which [Am]all new [D]carbons enter
[G]Structured [C]so as [G]to pre[Em]vent a
[G]Prema[D]ture re[G]lease

[REFRAIN 3]
[D]First one on the scene I'll
[G]Say is pantothenyl
On [G]ACP, as we shall see,
[G]A carrier of acyl groups, but meanwhile
[C]There's an [G]outer [Am]thiol [G]station
[Am]Much involved in [D]condensation
[G]Starts off [C]with an [G]acy[Em]lation
[G]By an [D]ace[G]tyl.

[VERSE 7]
[G]Firstly, [C]now that's [G]all been [Em]stated
[C] [Am] [D]
[A]-P-[Cs] malonylated,
[G]Which of [C]course is [G]inte[Em]grated
[G]With Co[D]A re[G]lease.

[VERSE 8]
[G]Now [C]there is [G]a new [Em]ligation
[C]Paid by [Am]decar[D]boxylation
[G]Ace[C]tyl from [G]outer [Em]station
[G]Makes a [D]C4 [G]piece.

[REFRAIN 3]
[D]Really it's quite neat, oh!
[G]Nature doesn't veto
What [G]we've just seen, on methylene
[G]Gives ACP with acyl Beta keto,
[C]A-C-[G]P now [Am]acts as [G]hinging,
[Am]Keto acyl [D]is now swinging
[G]Till its [C]keto [G]group it's [Em]bringing
[G]To the [D]reduc[G]tase.

[VERSE 9]
[G]If when [C]we're me[G]tabo[Em]lising
[C]It's for [Am]bio[D]synthesising
[G] [C] [G] [Em]
N-[A]-[D]-P-[H] arising
[G]Has a [D]rea[G]dy use.

[VERSE 10]
[G]Pentose [C]phosphate [G]H[Em] -extraction,
[C]Also [Am]malic [D]enzyme action,
[G]All in [C]cyto[G]solic [Em]fraction,
[G]All se[D]t to re[G]duce

[REFRAIN 4]
[D]Keto group reduction,
[G]Hydroxy construction
[G]On A-C-P, so never free,
[G]Hydroxy Beta butyryl production,
[C]Next we [G]swing to [Am]dehy[G]dration,
[Am] [D]
Enoyl [A]-[C]-P formation,
[G]Then a [C]new hy[G]droge[Em]nation
[G]Satu[D]rates [G]the chain.

[VERSE 11]
[G]Acyl [C]fate is [G]now trans[Em]feral
[C]To free [Am]thiols [D]peripheral,
[G]Panto[C]thenyls [G]thus pre[Em]pare all,
[G]For the [D]next [G]attack,

[VERSE 12]
[G]As in [C]circuit [G]we've just [Em]ended
[C]Malo[Am]nyl is [D]apprehended,
[G] [C] [G] [Em]
A-[C]-P again appended,
[G]C4 [D]now pas[G]sed back,

[REFRAIN 5]
[D]Bicarb, generating,
[G]C6 thus creating,
[G]Again we've got, on Beta spot,
[G]A keto in the chain we're saturating,
[C]That's re[G]duced, [Am]then dehy[G]drated,
[Am]Double bond e[D]liminated,
[G]Now re[C]peat, till [G]we've cre[Em]ated
[G]Palmi[D]toyl [G]CoA!